Browse by author
Lookup NU author(s): Professor Vinidh Paleri, Dr Max RobinsonORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
BackgroundThe purpose of this study was to present the clinicopathological features of a series of patients with human papillomavirus (HPV)-associated head and neck second primary tumors.MethodsPatients with HPV-associated head and neck second primary tumors from 3 centers were identified. HPV infection was evaluated using p16 by immunohistochemistry (IHC), high-risk HPV DNA by in situ hybridization (ISH), and HPV genotyping by DNA polymerase chain reaction (PCR) enzyme immunoassay (EIA).ResultsEleven patients were identified: 5 with synchronous and 6 with metachronous HPV-positive second primary tumors, the latter demonstrating a mean time interval of 5 years. There were 13 second primary tumors: 11 oropharyngeal, 1 nasopharyngeal, and 1 floor of the mouth. Nine of 10 genotyped patients harbored HPV-16, and 1 patient had HPV-33 in 3 synchronous tumors.ConclusionHPV-associated second primary tumors may present as synchronous and/or metachronous lesions and can arise outside the oropharynx after prolonged intervals. Further work is necessary to identify patients at risk and to elucidate the mechanisms of HPV-associated head and neck second primary tumors. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 202-208, 2015
Author(s): Caley A, Evans M, Powell N, Paleri V, Tomkinson A, Urbano TG, Jay A, Robinson M, Thavaraj S
Publication type: Article
Publication status: Published
Journal: Head & Neck
Year: 2015
Volume: 37
Issue: 2
Pages: 202-208
Print publication date: 01/02/2015
Online publication date: 20/03/2014
Acceptance date: 18/12/2013
ISSN (print): 1043-3074
ISSN (electronic): 1097-0347
Publisher: John Wiley & Sons, Inc.
URL: http://dx.doi.org/10.1002/hed.23584
DOI: 10.1002/hed.23584
Altmetrics provided by Altmetric
