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Multicentric human papillomavirus-associated head and neck squamous cell carcinoma

Lookup NU author(s): Professor Vinidh Paleri, Dr Max RobinsonORCiD


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BackgroundThe purpose of this study was to present the clinicopathological features of a series of patients with human papillomavirus (HPV)-associated head and neck second primary tumors.MethodsPatients with HPV-associated head and neck second primary tumors from 3 centers were identified. HPV infection was evaluated using p16 by immunohistochemistry (IHC), high-risk HPV DNA by in situ hybridization (ISH), and HPV genotyping by DNA polymerase chain reaction (PCR) enzyme immunoassay (EIA).ResultsEleven patients were identified: 5 with synchronous and 6 with metachronous HPV-positive second primary tumors, the latter demonstrating a mean time interval of 5 years. There were 13 second primary tumors: 11 oropharyngeal, 1 nasopharyngeal, and 1 floor of the mouth. Nine of 10 genotyped patients harbored HPV-16, and 1 patient had HPV-33 in 3 synchronous tumors.ConclusionHPV-associated second primary tumors may present as synchronous and/or metachronous lesions and can arise outside the oropharynx after prolonged intervals. Further work is necessary to identify patients at risk and to elucidate the mechanisms of HPV-associated head and neck second primary tumors. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 202-208, 2015

Publication metadata

Author(s): Caley A, Evans M, Powell N, Paleri V, Tomkinson A, Urbano TG, Jay A, Robinson M, Thavaraj S

Publication type: Article

Publication status: Published

Journal: Head & Neck

Year: 2015

Volume: 37

Issue: 2

Pages: 202-208

Print publication date: 01/02/2015

Online publication date: 20/03/2014

Acceptance date: 18/12/2013

ISSN (print): 1043-3074

ISSN (electronic): 1097-0347

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/hed.23584


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