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Non-alcoholic fatty liver disease: a practical approach to treatment

Lookup NU author(s): Dr Jess Dyson, Professor Quentin AnsteeORCiD, Professor Stuart McPhersonORCiD


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Non-alcoholic fatty liver disease (NAFLD) affects up to a third of the population in many developed countries. Between 10% and 30% of patients with NAFLD have non-alcoholic steatohepatitis (NASH) that can progress to cirrhosis. There are metabolic risk factors common to both NAFLD and cardiovascular disease, so patients with NASH have an increased risk of liver-related and cardiovascular death. Management of patients with NAFLD depends largely on the stage of disease, emphasising the importance of careful risk stratification. There are four main areas to focus on when thinking about management strategies in NAFLD: lifestyle modification, targeting the components of the metabolic syndrome, liver-directed pharmacotherapy for high risk patients and managing the complications of cirrhosis.

Publication metadata

Author(s): Dyson JK, Anstee QM, McPherson S

Publication type: Review

Publication status: Published

Journal: Postgraduate Medical Journal

Year: 2015

Volume: 91

Issue: 1072

Pages: 92-101

Print publication date: 01/02/2015

Online publication date: 22/01/2014

Acceptance date: 01/01/2014

ISSN (print): 0032-5473

ISSN (electronic): 1469-0756



DOI: 10.1136/postgradmedj-2013-100404rep