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OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome

Lookup NU author(s): Dr Hannah Sinclair, Dr Alan Bagnall, Professor Vijay KunadianORCiD


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After 2 decades of development and use in interventional cardiology research, optical coherence tomography (OCT) has now become a core intravascular imaging modality in clinical practice. Its unprecedented spatial resolution allows visualization of the key components of the atherosclerotic plaque that appear to confer "vulnerability" to rupture namely the thickness of the fibrous cap, size of the necrotic core, and the presence of macrophages. The utility of OCT in the evaluation of plaque composition can provide insights into the pathophysiology of acute coronary syndrome and the healing that occurs thereafter. A brief summary of the principles of OCT technology and a comparison with other intravascular imaging modalities is presented. The review focuses on the current evidence for the use of OCT in identifying vulnerable plaques in acute coronary syndrome and its limitations. (C) 2015 by the American College of Cardiology Foundation.

Publication metadata

Author(s): Sinclair H, Bourantas C, Bagnall A, Mintz GS, Kunadian V

Publication type: Article

Publication status: Published

Journal: JACC-Cardiovascular Imaging

Year: 2015

Volume: 8

Issue: 2

Pages: 198-209

Print publication date: 01/02/2015

Online publication date: 09/02/2015

Acceptance date: 09/12/2014

ISSN (print): 1936-878X

ISSN (electronic): 1876-7591

Publisher: Elsevier


DOI: 10.1016/j.jcmg.2014.12.005


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