Browse by author
Lookup NU author(s): Anne Chambers,
Dr Max RobinsonORCiD,
Professor Philip Sloan
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Objective. This study presents the clinicopathologic features of a series (N = 35) of patients with non-human immunodeficiency virus (HIV)-associated oral hairy leukoplakia (OHL).Methods. Patients with non-HIV-associated OHL were identified from three centers. Epstein-Barr virus infection was demonstrated by using EBV early ribonucleic acid in situ hybridization. The presence of Candida co-infection was evaluated by diastase periodic acid-Schiff staining. The clinical features were determined by review of the medical records.Results. Twenty-eight patients had intercurrent respiratory problems requiring long-term steroid inhaler use, four suffered from autoimmune diseases requiring immunosuppressant therapy, and four had diabetes. The majority of lesions were located on the tongue, and 24 showed evidence of Candida co-infection.Conclusions. In the twenty-first century, the presence of OHL should not be regarded as pathognomic for HIV infection or significant systemic immunosuppression. Local and systemic immunosuppression, in the form of steroid inhaler use, is a risk factor for the development of OHL.
Author(s): Chambers AE, Conn B, Pemberton M, Robinson M, Banks R, Sloan P
Publication type: Article
Publication status: Published
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Print publication date: 01/03/2015
Online publication date: 05/12/2015
Acceptance date: 19/11/2014
ISSN (print): 2212-4403
ISSN (electronic): 1528-395X
Altmetrics provided by Altmetric