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Lookup NU author(s): Professor Stuart Baker
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
To identify the correlates of a single cortical action potential in surface EEG, we recorded simultaneously epidural EEG and single-unit activity in the primary somatosensory cortex of awake macaque monkeys. By averaging over EEG segments coincident with more than hundred thousand single spikes, we found short-lived (approximate to 0.5 ms) triphasic EEG deflections dominated by high-frequency components >800 Hz. The peak-to-peak amplitude of the grand-averaged spike correlate was 80 nV, which matched theoretical predictions, while single-neuron amplitudes ranged from 12 to 966 nV. Combining these estimates with post-stimulus-time histograms of single-unit responses to median-nerve stimulation allowed us to predict the shape of the evoked epidural EEG response and to estimate the number of contributing neurons. These findings establish spiking activity of cortical neurons as a primary building block of high-frequency epidural EEG, which thus can serve as a quantitative macroscopic marker of neuronal spikes. (C) 2015 The Authors. Published by Elsevier Inc.
Author(s): Telenczuk B, Baker SN, Kempter R, Curio G
Publication type: Article
Publication status: Published
Print publication date: 01/04/2015
Online publication date: 29/12/2014
Acceptance date: 19/12/2014
Date deposited: 29/06/2015
ISSN (print): 1053-8119
ISSN (electronic): 1095-9572
PubMed id: PMC4349634
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