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Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study

Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska, Zeinab Abdel-All, Dr Joana Andrade, Professor John O'Brien, Professor Raj KalariaORCiD

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Abstract

BackgroundClusterin protein in plasma has been found to differentiate between people with and without cognitive changes. However, these findings are not conclusive, despite the clusterin gene variations repeatedly being linked to increased risk for dementia, in particular Alzheimer's disease (AD).MethodWe analysed the level of clusterin in platelet and plasma in 25 subjects with a clinical diagnosis of AD and 26 subjects with no cognitive impairment.ResultsIn the current study, we report that the levels of both plasma and platelet clusterin are similar between AD and cognitively intact individuals. Clusterin plasma and platelet levels, as well as the plasma/platelet clusterin ratio, were not affected by age, gender, cognitive impairment and/or overt behavioural symptomatology, including presence of hallucinations and delusions, as well as depression. However, the plasma/platelet clusterin ratio was positively associated in with the Neuropsychiatric Inventory measures of agitation, apathy, irritability and motor aberrant behaviour in AD subjects.ConclusionPrevious inconsistencies in reported blood clusterin levels may be a result of underlying non-cognitive symptoms in people with AD. Our findings need now to be replicated in larger group of dementia subjects. Copyright (c) 2014 John Wiley & Sons, Ltd.

Publication metadata

Author(s): Mukaetova-Ladinska EB; Kalaria RN; O'Brien JT; Abdel-All Z; Andrade J; da Silva JA

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2015

Volume: 30

Issue: 4

Pages: 368-375

Print publication date: 01/04/2015

Online publication date: 12/06/2014

Acceptance date: 25/04/2014

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/gps.4145

DOI: 10.1002/gps.4145

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