Toggle Main Menu Toggle Search

Open Access padlockePrints

Effects of co-administration of a monoamine oxidase inhibitor and a 5-HT1A receptor antagonist on 5-hydroxytryptamine cell firing and release

Lookup NU author(s): Dr Sasha Gartside


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


We report the effects of the monoamine oxidase inhibitor, tranylcypromine, combined with the 5-HT1A receptor antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl cyclohexanecarboxamide (WAY 100635), on both 5-hydroxytryptamine (5-HT) cell firing and cortical extracellular 5-HT in the rat. Tranylcypromine inhibited 5-HT cell firing in the dorsal raphe nucleus dose-dependently (ED50 5 mg/kg i.v.). In microdialysis experiments, tranylcypromine (5 mg/kg i.v.) increased extracellular 5-HT in the frontal cortex. WAY 100635 (0.1 mg/kg i.v.) both reversed the inhibition of 5-HT cell firing and facilitated the increase in extracellular 5-HT. In conclusion, WAY 100635 enhances the effect of tranylcypromine on presynaptic 5-HT function. These data are relevant to clinical evidence that co-therapy with a 5-HT1A receptor antagonist improves the antidepressant efficacy of a monoamine oxidase inhibitor.

Publication metadata

Author(s): Sharp T, Gartside SE, Umbers V

Publication type: Article

Publication status: Published

Journal: European Journal of Pharmacology

Year: 1997

Volume: 320

Issue: 1

Pages: 15-19

Print publication date: 05/02/1997

ISSN (print): 0014-2999

ISSN (electronic): 1879-0712

Publisher: Elsevier


DOI: 10.1016/S0014-2999(96)00968-5

Notes: 0014-2999 (Print) Journal Article


Altmetrics provided by Altmetric