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The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Lookup NU author(s): Dr Michael FirbankORCiD


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Background: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.Methods: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.Results: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).Conclusions: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, Liu YW, Preboske G, Swihart T, Blair M, Cavedo E, Grothe MJ, Lanfredi M, Martinez O, Nishikawa M, Portegies M, Stoub T, Ward C, Apostolova LG, Ganzola R, Wolf D, Barkhof F, Bartzokis G, DeCarli C, Csernansky JG, DeToledo-Morrell L, Geerlings MI, Kaye J, Killiany RJ, Lehericy S, Matsuda H, O'Brien J, Silbert LC, Scheltens P, Soininen H, Teipel S, Waldemar G, Fellgiebel A, Barnes J, Firbank M, Gerritsen L, Henneman W, Malykhin N, Pruessner JC, Wang L, Watson C, Wolf H, deLeon M, Pantel J, Ferrari C, Bosco P, Pasqualetti P, Duchesne S, Duvernoy H, Boccardi M, EADC-ADNI Working Grp Harmonized P, Alzheimers Dis Neuroimaging Initia

Publication type: Article

Publication status: Published

Journal: Alzheimer's & Dementia

Year: 2015

Volume: 11

Issue: 2

Pages: 111-125

Print publication date: 01/02/2015

Online publication date: 27/09/2014

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: Elsevier


DOI: 10.1016/j.jalz.2014.05.1756


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Funder referenceFunder name
ADNI clinical sites in Canada
Alzheimer's Research UK
Brain Research Trust
Lilly International
Ministere du Developpement Economique, de l'Innovation et de l'Exportation of Quebec
National Institute on Aging
NIHR Queen Square Dementia BRU
National Institute of Biomedical Imaging and Bioengineering
Wyeth International
ANR-10-IAIHU-06Investissements d' avenir
IIRG-10-174022Alzheimer's Association
K01 AG030514NM grants
P30 AG008017NIH/NIA ADC P30 grant
P30 AG010129NM grants
U01 AG024904Alzheimer's Disease Neuroimaging Initiative (ADM) (National Institutes of Health)