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Lookup NU author(s): Dr Michael FirbankORCiD
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Background: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.Methods: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.Results: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.Discussion: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Author(s): Boccardi M, Bocchetta M, Apostolova LG, Barnes J, Bartzokis G, Corbetta G, DeCarli C, DeToledo-Morrell L, Firbank M, Ganzola R, Gerritsen L, Henneman W, Killiany RJ, Malykhin N, Pasqualetti P, Pruessner JC, Redolfi A, Robitaille N, Soininen H, Tolomeo D, Wang L, Watson C, Wolf H, Duvernoy H, Duchesne S, Jack CR, Frisoni GB, EADC-ADNI Working Grp Harmonized P
Publication type: Article
Publication status: Published
Journal: Alzheimer's & Dementia
Year: 2015
Volume: 11
Issue: 2
Pages: 126-138
Print publication date: 01/02/2015
Online publication date: 15/08/2014
ISSN (print): 1552-5260
ISSN (electronic): 1552-5279
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.jalz.2014.02.009
DOI: 10.1016/j.jalz.2014.02.009
PubMed id: 25130658
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