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Lookup NU author(s): Dr Elizabeth Stoll, Professor Andrew Trevelyan, Dr Satomi Miwa, Emeritus Professor Doug Turnbull
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Neural activity is tightly coupled to energy consumption, particularly sugars such as glucose. Yet we find that, unlike mature neurons and astrocytes, neural stem/progenitor cells (NSPCs) do not require glucose to sustain aerobic respiration. NSPCs within the adult subventricular zone express enzymes required for fatty acid oxidation and show sustained increases in oxygen consumption upon treatment with a polyunsaturated fatty acid. NSPCs also demonstrate sustained decreases in oxygen consumption upon treatment with etomoxir, an inhibitor of fatty acid oxidation. In addition, etomoxir decreases the proliferation of subventricular zone NSPCs without affecting cellular survival. Finally, higher levels of neurogenesis can be achieved in aged mice by ectopically expressing PGC1a, a factor that increases cellular aerobic capacity by promoting mitochondrial biogenesis and metabolic gene transcription. Regulation of metabolic fuel availability could prove a powerful tool in promoting or limiting cellular proliferation in the central nervous system.
Author(s): Stoll EA, Makin R, Sweet IR, Trevelyan AJ, Miwa S, Horner PJ, Turnbull DM
Publication type: Article
Publication status: Published
Journal: Stem Cells
Year: 2015
Volume: 33
Issue: 7
Pages: 2306-2319
Print publication date: 01/07/2015
Online publication date: 27/04/2015
Acceptance date: 24/03/2015
Date deposited: 07/09/2015
ISSN (print): 1066-5099
ISSN (electronic): 1549-4918
Publisher: Wiley
URL: http://dx.doi.org/10.1002/stem.2042
DOI: 10.1002/stem.2042
PubMed id: PMC4478223
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