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Quantifying the correlation between photoplethysmography and laser Doppler flowmetry microvascular low-frequency oscillations

Lookup NU author(s): Costanzo Di Maria, Professor John AllenORCiD


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Photoplethysmography (PPG) and laser Doppler flowmetry (LDF) are two recognized optical techniques that can track low-frequency perfusion changes in microcirculation. The aim of this study was to determine, in healthy subjects, the correlation between the techniques for specific low-frequency bands previously defined for microcirculation. Twelve healthy male subjects (age range 18 to 50 years) were studied, with PPG and LDF signals recorded for 20 min from their right and left index (PPG) and middle (LDF) fingers. Wavelet analysis comprised dividing the low-frequency integral wavelet spectrum (IWS) into five established physiological bands relating to cardiac, respiratory, myogenic, neurogenic, and endothelial activities. The correlation between PPG and LDF was quantified using wavelet correlation analysis and Spearman correlation analysis of the median IWS amplitude. The median wavelet correlation between signals (right-left side average) was 0.45 (cardiac), 0.49 (respiratory), 0.86 (myogenic), 0.91 neurogenic), and 0.91 (endothelial). The correlation of IWS amplitude values (right-left side average) was statistically significant for the cardiac (rho = 0.64, p < 0.05) and endothelial (rho = 0.62, p < 0.05) bands. This pilot study has shown good correlation between PPG and LDF for specific physiological frequency bands. In particular, the results suggest that PPG has the potential to be a low-cost replacement for LDF for endothelial activity assessments. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)

Publication metadata

Author(s): Mizeva I, Di Maria C, Frick P, Podtaev S, Allen J

Publication type: Article

Publication status: Published

Journal: Journal of Biomedical Optics

Year: 2015

Volume: 20

Issue: 3

Print publication date: 12/03/2015

Online publication date: 12/03/2015

ISSN (print): 1083-3668

ISSN (electronic): 1560-2281

Publisher: SPIE - International Society for Optical Engineering


DOI: 10.1117/1.JBO.20.3.037007


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Funder referenceFunder name
14-15-00809Russian Scientific Fund