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Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity

Lookup NU author(s): Dr Chien-Yi ChangORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria is explored, comparing cyclic, aromatic, and linear chemical groups. A correlation is shown between bacterial attachment and a parameter derived from the partition coefficient and the number of rotatable bonds of the materials' pendant groups. This correlation is applicable to 86% of the hydrocarbon pendant moieties surveyed, quantitatively supporting the previous qualitative observation that bacteria are repelled from poly(meth)acrylates containing a hydrophilic ester group when the pendant group is both rigid and hydrophobic. This insight will help inform and predict the further development of polymers resistant to bacterial attachment.

Publication metadata

Author(s): Sanni O, Chang CY, Anderson DG, Langer R, Davies MC, Williams PM, Williams P, Alexander MR, Hook AL

Publication type: Article

Publication status: Published

Journal: Advanced Healthcare Materials

Year: 2015

Volume: 4

Issue: 5

Pages: 695-701

Print publication date: 02/04/2015

Online publication date: 09/12/2014

Acceptance date: 19/11/2014

Date deposited: 19/08/2015

ISSN (print): 2192-2640

ISSN (electronic): 2192-2659

Publisher: Wiley-Blackwell


DOI: 10.1002/adhm.201400648


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Funder referenceFunder name
European Union
085245Wellcome Trust