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Lookup NU author(s): Professor Bernard Keavney,
Professor Azfar Zaman,
Dr Mark De Belder
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BackgroundAround one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.MethodsThe relationship between LV function and 30-day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and 80 years) was studied in 246,840 patients in the UK between 2006 and 2011.ResultsPrevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P<0.0001). Poor LV function was independently associated with increased risk of 30-day mortality outcomes in all age groups (OR 5.65:95% CI 4.21-7.58, age <60 years; OR 5.07: 95% CI 3.91-6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64-5.57, 70 to <80 years and OR 4.83:95% CI 3.79-6.15, age 80 years).ConclusionsOur analysis suggests that worsening LV function is an important independent predictor of worse 30-day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. (c) 2014 Wiley Periodicals, Inc.
Author(s): Kwok CS, Anderson SG, McAllister KSL, Sperrin M, O'Kane PD, Keavney B, Nolan J, Myint PK, Zaman A, Buchan I, Ludman PF, de Belder MA, Mamas MA, British Cardiovasc Intervention, Natl Inst Cardiovasc Outcomes Res
Publication type: Article
Publication status: Published
Journal: Catheterization and Cardiovascular Intervention
Print publication date: 01/05/2015
Online publication date: 27/11/2014
Acceptance date: 02/11/2014
ISSN (print): 1522-1946
ISSN (electronic): 1522-726X
Publisher: John Wiley & Sons, Inc.
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