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Impact of Age on the Prognostic Value of Left Ventricular Function in Relation to Procedural Outcomes Following Percutaneous Coronary Intervention: Insights From the British Cardiovascular Intervention Society

Lookup NU author(s): Professor Bernard Keavney, Professor Azfar Zaman, Dr Mark De Belder


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BackgroundAround one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.MethodsThe relationship between LV function and 30-day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and 80 years) was studied in 246,840 patients in the UK between 2006 and 2011.ResultsPrevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P<0.0001). Poor LV function was independently associated with increased risk of 30-day mortality outcomes in all age groups (OR 5.65:95% CI 4.21-7.58, age <60 years; OR 5.07: 95% CI 3.91-6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64-5.57, 70 to <80 years and OR 4.83:95% CI 3.79-6.15, age 80 years).ConclusionsOur analysis suggests that worsening LV function is an important independent predictor of worse 30-day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. (c) 2014 Wiley Periodicals, Inc.

Publication metadata

Author(s): Kwok CS, Anderson SG, McAllister KSL, Sperrin M, O'Kane PD, Keavney B, Nolan J, Myint PK, Zaman A, Buchan I, Ludman PF, de Belder MA, Mamas MA, British Cardiovasc Intervention, Natl Inst Cardiovasc Outcomes Res

Publication type: Article

Publication status: Published

Journal: Catheterization and Cardiovascular Intervention

Year: 2015

Volume: 85

Issue: 6

Pages: 944-951

Print publication date: 01/05/2015

Online publication date: 27/11/2014

Acceptance date: 02/11/2014

ISSN (print): 1522-1946

ISSN (electronic): 1522-726X

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/ccd.25732


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Funder referenceFunder name
MC_PC_13042Medical Research Council
MR/K006665/1Medical Research Council