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Lookup NU author(s): Dr Miguel Velazquez
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Malnutrition (i.e. undernutrition and overnutrition) is a world-wide phenomenon that can affect mammalian oocyte developmental competence following fertilization, compromising the establishment of pregnancy. However, live birth is usually possible during maternal malnutrition even in extremes cases of undernutrition (i.e. anorexia nervosa) and overnutrition (i.e. morbid obesity). Several epidemiological and clinical studies in humans and experimental animal models have demonstrated that in utero development under nutritional stress can program the development of non-communicable diseases (NCD) in adult life (e.g. diabetes, metabolic syndrome). Of further significance is the fact that malnutrition can also program the development of NCD in adulthood via changes on oocyte physiology before conception. This chapter focuses on the available evidence supporting this latter hypothesis.
Author(s): Velazquez MA, Fleming TP
Editor(s): Coticchio G, Albertini DF, De Santis L
Publication type: Book Chapter
Publication status: Published
Book Title: Oogenesis
Print publication date: 12/10/2012
Library holdings: Search Newcastle University Library for this item