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Placental expression of adenosine A_2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: Interactions with placental renin-angiotensin system

Lookup NU author(s): Dr Judith Bulmer

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Abstract

Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal expression placental adenosine A(2A)R receptor and HIF-1 alpha in early pregnancy and at delivery in normotensive (NT) and pre-eclamptic (PE) women. Results were compared to our previously reported angiotensin receptor data.Expression of A(2A)R and HIF-1 alpha was highest at <= 10 weeks, positively correlated through pregnancy and was higher in PE than NT at delivery. The A(2A)R associated with the AT4R only in early pregnancy. We suggest adenosine and RAS may interact to promote placentation with a potential adaptation to poor placental perfusion in PE. (C) 2015 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Kurlak LO, Williams PJ, Bulmer JN, Pipkin FB, Mistry HD

Publication type: Article

Publication status: Published

Journal: Placenta

Year: 2015

Volume: 36

Issue: 5

Pages: 611-613

Print publication date: 01/05/2015

Online publication date: 24/02/2015

Acceptance date: 16/02/2015

ISSN (print): 0143-4004

ISSN (electronic): 1532-3102

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.placenta.2015.02.011

DOI: 10.1016/j.placenta.2015.02.011

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