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Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer’s disease

Lookup NU author(s): Dr Luis Peraza RodriguezORCiD, Professor John-Paul TaylorORCiD, Professor Marcus Kaiser



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


The clinical phenotype of dementia with Lewy bodies (DLB) is different from Alzheimer’s Disease (AD), suggesting a divergence between these diseases in terms of brain network organisation. To fully understand this, we studied functional networks from resting state functional magnetic resonance imaging (rs-fMRI) in cognitively matched DLB and AD patients. The DLB group demonstrated a generalized lower synchronization compared to the AD and healthy controls, and this was more severe for edges connecting distant brain regions. Global network measures were significantly different between DLB and AD. For instance, AD showed lower small-worldness than healthy controls, while DLB showed higher small-worldness (AD<controls<DLB), and this was also the case for global efficiency (DLB>controls>AD) and clustering coefficient (DLB<controls<AD). Differences were also found for nodal measures at brain regions associated with each disease. Finally, we found significant associations between network performance measures and global cognitive impairment and severity of cognitive fluctuations in DLB. These results show network divergences between DLB and AD which appear to reflect their neuropathological differences.

Publication metadata

Author(s): Peraza LR, Taylor J-P, Kaiser M

Publication type: Article

Publication status: Published

Journal: Neurobiology of Aging

Year: 2015

Volume: 36

Issue: 9

Pages: 2458-2467

Print publication date: 01/09/2015

Online publication date: 01/06/2015

Acceptance date: 23/05/2015

Date deposited: 29/06/2015

ISSN (print): 0197-4580

ISSN (electronic): 1558-1497

Publisher: Elsevier


DOI: 10.1016/j.neurobiolaging.2015.05.015

PubMed id: 26115566


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Funder referenceFunder name
National Institute for Health Research (NIHR)
Newcastle Biomedical Research Unit (BRU) based at Newcastle upon Tyne Hospitals NHS Trust
Newcastle University
EP/K026992/1Human Green Brain Project through EPSRC
WT088441MAIntermediate Clinical Fellowship
088441/Z/09/ZWellcome Trust