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Stroke genomics in people of African ancestry: charting new paths

Lookup NU author(s): Dr Rufus Akinyemi, Professor Raj Kalaria

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Abstract

One in six people worldwide will experience a stroke in his/her lifetime. While people in Africa carry a disproportionately higher burden of poor stroke outcomes, compared to the rest of the world, the exact contribution of genomic factors to this disparity is unknown. Despite noteworthy research into stroke genomics, studies exploring the genetic contribution to stroke among populations of African ancestry in the United States are few. Furthermore, genomics data in populations living in Africa are lacking. The wide genomic variation of African populations offers a unique opportunity to identify genomic variants with causal relationships to stroke across different ethnic groups. The Stroke Investigative Research and Educational Network (SIREN), a component of the Human Health and Heredity in Africa (H3Africa) Consortium, aims to explore genomic and environmental risk factors for stroke in populations of African ancestry in West Africa and the United States. In this article, we review the literature on the genomics of stroke with particular emphasis on populations of African origin.


Publication metadata

Author(s): Akinyemi RO, Ovbiagele B, Akpalu A, Jenkins C, Sagoe K, Owolabi L, Sarfo F, Obiako R, Gebreziabher M, Melikam E, Warth S, Arulogun O, Lackland D, Ogunniyi A, Tiwari H, Kalaria RN, Arnett D, Owolabi MO, SIREN, H3Africa Consortium

Publication type: Article

Publication status: Published

Journal: Cardiovascular Journal of Africa

Year: 2015

Volume: 26

Issue: 2 Suppl. 1

Pages: S39-S49

Print publication date: 01/03/2015

ISSN (print): 1995-1892

ISSN (electronic): 1680-0745

Publisher: Clinics - Cardive Publishing Co.

URL: http://dx.doi.org/10.5830/CVJA-2015-039

DOI: 10.5830/CVJA-2015-039


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