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Progressive cortical thinning and subcortical atrophy in dementia with Lewy bodies and Alzheimer's disease

Lookup NU author(s): Dr Michael FirbankORCiD, Professor Andrew BlamireORCiD, Professor John O'Brien


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Patterns of progressive cortical thinning in dementia with Lewy bodies (DLB) remain poorly understood. We examined spatiotemporal patterns of cortical thinning and subcortical atrophy over 12 months in DLB (n = 13), compared with Alzheimer's disease (AD) (n = 23) and healthy control subjects (HC) (n = 33). Rates of temporal thinning in DLB were relatively preserved compared with AD. Volumetric analyses subcortical changes revealed that the AD group demonstrated significantly increased hippocampal atrophy (-5.8%) relative to the HC (-1.7%; p < 0.001) and DLB groups (-2.5%, p = 0.006). Significant lateral ventricular expansion was also observed in AD (8.9%) compared with HC (4.3%; p < 0.001) and DLB (4.7%; p = 0.008) at trend level. There was no significant difference in subcortical atrophy and ventricular expansion between DLB and HC. In the DLB group, increased rates of cortical thinning in the frontal and parietal regions were significantly correlated with decline in global cognition (Mini-Mental State Examination) and motor deterioration (Unified Parkinson's Disease Rating Scale 3), respectively. Overall, AD and DLB are characterized by different spatiotemporal patterns of cortical thinning over time. Our findings warrant further consideration of longitudinal cortical thinning as a potential imaging marker to differentiate DLB from AD. Crown Copyright (C) 2015 Published by Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Mak E, Sua L, Williams GB, Watson R, Firbank MJ, Blamire AM, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Neurobiology of Aging

Year: 2015

Volume: 36

Issue: 4

Pages: 1743-1750

Print publication date: 01/04/2015

Online publication date: 08/01/2015

Acceptance date: 30/12/2014

ISSN (print): 0197-4580

ISSN (electronic): 1558-1497

Publisher: Elsevier


DOI: 10.1016/j.neurobiolaging.2014.12.038


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Funder referenceFunder name
Newcastle University
NIHR Biomedical Research Unit in Dementia
Biomedical Research Centre award
Gates Cambridge PhD studentship
University of Cambridge
05/JTASir Jules Thorn Charitable Trust