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Antisense effects of PNAs in bacteria

Lookup NU author(s): Dr James StachORCiD

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Abstract

Peptide nucleic acids (PNAs) are a class of artificial DNA/RNA analogues that have unique physicochemical properties, which include a high chemical stability, resistance to nucleases and proteases and higher mismatch sensitivity than DNA. PNAs were initially anticipated to be useful for application in antisense and antigene therapies; however, their poor cellular uptake has limited their use for such purposes in the "real world". Recently, it has been shown that the addition of metal complexes to these oligonucleotide analogues could open up new avenues for their utilization in various research fields. Such metallo-constructs have shown great promise, for a diverse range of applications, most notably in the biosensing area. In this chapter, we report on the recent synthetic advances towards the preparation of these "(multi)-metallic PNAs" on the solid phase.

Publication metadata

Author(s): Goh S, Stach JEM, Good L

Publication type: Article

Publication status: Published

Journal: Methods in Molecular Biology

Year: 2014

Volume: 1050

Pages: 223-236

Online publication date: 09/11/2013

ISSN (electronic): 1064-3745

Publisher: Springer

URL: http://dx.doi.org/10.1007/978-1-62703-553-8_18

DOI: 10.1007/978-1-62703-553-8_18

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