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Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples

Lookup NU author(s): Dr Tevfik Dorak

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Abstract

Factors that might increase risk of HIV-1 transmission include age, sex, and amount of HIV-1 RNA in plasma, but findings for HLA allele-sharing are not in agreement. We tested the hypothesis that allele sharing at HLA loci is associated with increased risk of transmission of HIV-1 infection in cohabiting heterosexual Zambian couples. We studied 125 initially serodiscordant partners with sequence-confirmed interpartner HIV-1 transmission and 104 couples who were persistently serodiscordant, and we analysed relations with molecularly typed HLA-A, B, and C alleles by survival techniques. After adjustment for other genetic and non-genetic risk factors seen with heterosexual transmission of HIV-1 in this cohort, sharing of HLA-B alleles was independently associated with accelerated intracouple transmission (relative hazard 2.23, 95% CI 1.52-3.26, p<0.0001). Selective pressure by HLA-B alleles on transmitted viruses accords with current understanding of the effect of B locus polymorphism in HIV-1 and perhaps other infections.

Publication metadata

Author(s): Dorak MT, Tang J, Penman-Aguilar A, Westfall AO, Zulu I, Lobashevsky ES, Kancheya NG, Schaen MM, Allen SA, Kaslow RA

Publication type: Article

Publication status: Published

Journal: The Lancet

Year: 2004

Volume: 363

Issue: 9427

Pages: 2137-2139

Print publication date: 25/06/2004

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group

URL: http://dx.doi.org/10.1016/S0140-6736(04)16505-7

DOI: 10.1016/S0140-6736(04)16505-7

PubMed id: 15220037

Notes: 1474-547x Journal Article

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