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Resting state in Parkinson’s disease dementia and dementia with Lewy bodies: Commonalities and differences

Lookup NU author(s): Dr Luis Peraza RodriguezORCiD, Dr Sean Colloby, Dr Michael FirbankORCiD, Shirmin Greasy, Professor Ian McKeith, Professor Marcus Kaiser, Professor John O'Brien, Professor John-Paul TaylorORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Objective. Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are two dementias with overlapping phenotypes. Clinically, these are differentiated by the one year precedence rule between the onset of dementia with respect to Parkinsonism. In this report we aimed to find differences between DLB and PDD in functional connectivity (FC) using resting state functional magnetic resonance imaging (rs-fMRI) which we hypothesized would reflect the underlying pathological differences between DLB and PDD. Methods. The study cohort comprised of 18 patients with DLB, 12 with PDD and 17 healthy controls (HC). Eight cortical and four subcortical seeds were chosen and time series extracted to estimate correlation maps. We also implemented a voxel based morphometry (VBM) analysis to assess regional grey matter differences. FC analysis was corrected for age, sex and regional grey matter differences. Results. The FC analysis showed greater alterations in DLB than in PDD for seeds placed within the fronto-parietal network (FPN), while in contrast, for the supplementary motor area seed FC alterations were more apparent in PDD than in DLB. However, when comparing DLB and PDD, no significant differences were found. In addition, VBM analysis revealed greater atrophy in PDD than HC and DLB in the bilateral motor cortices and precuneus respectively.Conclusions. PDD and DLB demonstrate similar FC alterations in the brain. However, attention and motor related seeds revealed subtle differences between both conditions when compared to HC, which may relate to the neuropathology and chronological precedence of core symptoms in the Lewy body dementias.

Publication metadata

Author(s): Peraza LR, Colloby SJ, Firbank MJ, Greasy SG, McKeith IG, Kaiser M, O'Brien J, Taylor JP

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2015

Volume: 30

Issue: 11

Pages: 1135-1146

Print publication date: 01/11/2015

Online publication date: 13/08/2015

Acceptance date: 14/07/2015

Date deposited: 17/08/2015

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: John Wiley & Sons Ltd.


DOI: 10.1002/gps.4342

PubMed id: 26270627


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Funder referenceFunder name
National Institute for Health Research Newcastle Biomedical Research Unit, based at Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle University
WT088441MAIntermediate Clinical Fellowship
088441/Z/09/ZWellcome Trust