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Lookup NU author(s): Dr Luis Peraza RodriguezORCiD, Dr Sean Colloby, Dr Michael FirbankORCiD, Shirmin Greasy, Professor Ian McKeith, Professor Marcus Kaiser, Professor John O'Brien, Professor John-Paul TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Objective. Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are two dementias with overlapping phenotypes. Clinically, these are differentiated by the one year precedence rule between the onset of dementia with respect to Parkinsonism. In this report we aimed to find differences between DLB and PDD in functional connectivity (FC) using resting state functional magnetic resonance imaging (rs-fMRI) which we hypothesized would reflect the underlying pathological differences between DLB and PDD. Methods. The study cohort comprised of 18 patients with DLB, 12 with PDD and 17 healthy controls (HC). Eight cortical and four subcortical seeds were chosen and time series extracted to estimate correlation maps. We also implemented a voxel based morphometry (VBM) analysis to assess regional grey matter differences. FC analysis was corrected for age, sex and regional grey matter differences. Results. The FC analysis showed greater alterations in DLB than in PDD for seeds placed within the fronto-parietal network (FPN), while in contrast, for the supplementary motor area seed FC alterations were more apparent in PDD than in DLB. However, when comparing DLB and PDD, no significant differences were found. In addition, VBM analysis revealed greater atrophy in PDD than HC and DLB in the bilateral motor cortices and precuneus respectively.Conclusions. PDD and DLB demonstrate similar FC alterations in the brain. However, attention and motor related seeds revealed subtle differences between both conditions when compared to HC, which may relate to the neuropathology and chronological precedence of core symptoms in the Lewy body dementias.
Author(s): Peraza LR, Colloby SJ, Firbank MJ, Greasy SG, McKeith IG, Kaiser M, O'Brien J, Taylor JP
Publication type: Article
Publication status: Published
Journal: International Journal of Geriatric Psychiatry
Year: 2015
Volume: 30
Issue: 11
Pages: 1135-1146
Print publication date: 01/11/2015
Online publication date: 13/08/2015
Acceptance date: 14/07/2015
Date deposited: 17/08/2015
ISSN (print): 0885-6230
ISSN (electronic): 1099-1166
Publisher: John Wiley & Sons Ltd.
URL: http://dx.doi.org/10.1002/gps.4342
DOI: 10.1002/gps.4342
PubMed id: 26270627
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