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Lookup NU author(s): Dr Peter Massey
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It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.
Author(s): Massey PV, Warburton EC, Wynick D, Brown MW, Bashir ZI
Publication type: Article
Publication status: Published
Journal: Neuropharmacology
Year: 2003
Volume: 44
Issue: 1
Pages: 40-48
Print publication date: 22/01/2003
Online publication date: 22/01/2003
Acceptance date: 29/08/2002
ISSN (print): 0028-3908
ISSN (electronic): 1873-7064
Publisher: Pergamon Press
URL: http://www.sciencedirect.com/science/article/pii/S0028390802002976
DOI: 10.1016/S0028-3908(02)00297-6
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