Toggle Main Menu Toggle Search

Open Access padlockePrints

Cortical Thickness in Dementia with Lewy Bodies and Alzheimer's Disease: A Comparison of Prodromal and Dementia Stages

Lookup NU author(s): Dr Frederic Blanc, Dr Sean Colloby, Professor Alan ThomasORCiD, Professor John O'Brien, Professor Ian McKeith, Professor John-Paul TaylorORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


ObjectivesTo assess and compare cortical thickness (CTh) of patients with prodromal Dementia with Lewy bodies (pro-DLB), prodromal Alzheimer's disease (pro-AD), DLB dementia (DLB-d), AD dementia (AD-d) and normal ageing.MethodsStudy participants(28 pro-DLB, 27 pro-AD, 31 DLB-d, 54 AD-d and 33 elderly controls) underwent 3Tesla T1 3D MRI and detailed clinical and cognitive assessments. We used Free-Surfer analysis package to measure CTh and investigate patterns of cortical thinning across groups.ResultsComparison of CTh between pro-DLB and pro-AD (p<0.05, FDR corrected) showed more right anterior insula thinning in pro-DLB, and more bilateral parietal lobe and left parahippocampal gyri thinning in pro-AD. Comparison of prodromal patients to healthy elderly controls showed the involvement of the same regions. In DLB-d (p<0.05, FDR corrected) cortical thinning was found predominantly in the right temporo-parietal junction, and insula, cingulate, orbitofrontal and lateral occipital cortices. In AD-d(p<0.05, FDR corrected), the most significant areas affected included the entorhinal cortices, parahippocampal gyri and parietal lobes. The comparison of AD-d and DLB-d demonstrated more CTh in AD-d in the left entorhinal cortex (p<0.05, FDR corrected).ConclusionCortical thickness is a sensitive measure for characterising patterns of grey matter atrophy in early stages of DLB distinct from AD. Right anterior insula involvement may be a key region at the prodromal stage of DLB and needs further investigation.

Publication metadata

Author(s): Blanc F, Colloby SJ, Philippi N, de Petigny X, Jung B, Demuynck C, Phillipps C, Anthony P, Thomas A, Bing F, Lamy J, Martin-Hunyadi C, O'Brien JT, Cretin B, McKeith I, Armspach JP, Taylor JP

Publication type: Article

Publication status: Published

Journal: PLoS ONE

Year: 2015

Volume: 10

Issue: 6

Online publication date: 10/06/2015

Acceptance date: 15/04/2015

Date deposited: 18/08/2015

ISSN (electronic): 1932-6203

Publisher: Public Library of Science


DOI: 10.1371/journal.pone.0127396


Altmetrics provided by Altmetric


Funder referenceFunder name
Alsace Alzheimer 67
Appel a Projet Interne (API) of the University Hospital of Strasbourg
Fondation Universite de Strasbourg and famille Jean Amrhein
NIHR Dementia Biomedical Research Unit at Cambridge University Hospitals NHS Foundation Trust
Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals NHS Foundation Trust
National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre in Ageing and Chronic Disease
Newcastle University
University of Cambridge
BH0070250Newcastle Healthcare Charity
BH083281Wellcome Intermediate Clinical Fellowship
BH090112Academy of Medical Sciences, Wellcome Trust
IDRCB 2012-A00992-41Projet Hospitalier de Recherche Clinique (PHRC)