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Temporal clustering of neuroblastic tumours in children and young adults from Northern England

Lookup NU author(s): Dr Colin Muirhead, Professor Deborah Tweddle, Nermine Basta, Dr Richard McNally

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

BACKGROUND: The aetiology of neuroblastic tumours is unclear with both genetic and environmental factors implicated. The possibility that an infectious agent may be involved has been suggested. 'Temporal clustering' occurs if cases display an irregular temporal distribution and may indicate the involvement of an agent that exhibits epidemicity. We tested for the presence and nature of temporal clustering using population-based data from northern England. METHODS: We extracted all cases of neuroblastic tumours diagnosed in children and young adults aged 0-24 years during 1968-2011 from the Northern Region Young Persons' Malignant Disease Registry. This is a population-based registry, covering a population of approximately 900,000 young persons, and includes all cases resident in northern England at the time of diagnosis. Tests for temporal clustering were applied using a modified version of the Potthoff-Whittinghill method. Estimates of extra-Poisson variation ([Formula: see text]) and standard errors (SEs) were obtained. RESULTS: 227 cases of neuroblastic tumours were diagnosed during the study period. All the analyses between fortnights and between months found significant extra-Poisson variation, with [Formula: see text] =0.846 (SE = 0.310, P = 0.004) for the analysis between fortnights within months. Restricting the analyses to the 76 cases diagnosed at ages less than 18 months showed significant extra-Poisson variation between fortnights within months ([Formula: see text] =1.532, SE = 0.866, P = 0.038), but not between months. In contrast, analyses of cases aged 18 months to 24 years showed significant extra-Poisson variation between quarters within years, as well as over shorter timescales. CONCLUSIONS: Transient environmental agents may be involved in the aetiology of neuroblastic tumours. The initiating factor might be a geographically-widespread agent that occurs in 'mini-epidemics'.


Publication metadata

Author(s): Muirhead CR, Tweddle DA, Basta NO, McNally RJQ

Publication type: Article

Publication status: Published

Journal: Environmental Health

Year: 2015

Volume: 14

Issue: 1

Online publication date: 04/09/2015

Acceptance date: 29/08/2015

Date deposited: 08/09/2015

ISSN (electronic): 1476-069X

Publisher: BioMed Central Ltd.

URL: http://dx.doi.org/10.1186/s12940-015-0058-z

DOI: 10.1186/s12940-015-0058-z

PubMed id: 26338008


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