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Lookup NU author(s): Martina Miotto,
Dr Ricardo Martins GouveiaORCiD,
Professor Che ConnonORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The increasing interest in effort towards creating alternative therapies have led to exciting breakthroughs in the attempt to bio-fabricate and engineer live tissues. This has been particularly evident in the development of new approaches applied to reconstruct corneal tissue. The need for tissue-engineered corneas is largely a response to the shortage of donor tissue and the lack of suitable alternative biological scaffolds preventing the treatment of millions of blind people worldwide. This review is focused on recent developments in corneal tissue engineering, specifically on the use of self-assembling peptide amphiphiles for this purpose. Recently, peptide amphiphiles have generated great interest as therapeutic molecules, both in vitro and in vivo. Here we introduce this rapidly developing field, and examine innovative applications of peptide amphiphiles to create natural bio-prosthetic corneal tissue in vitro. The advantages of peptide amphiphiles over other biomaterials, namely their wide range of functions and applications, versatility, and transferability are also discussed to better understand how these fascinating molecules can help solve current challenges in corneal regeneration.
Author(s): Miotto M, Gouveia RM, Connon CJ
Publication type: Article
Publication status: Published
Journal: Journal of Functional Biomaterials
Online publication date: 06/08/2015
Acceptance date: 03/08/2015
Date deposited: 24/09/2015
ISSN (electronic): 2079-4983
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