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Lookup NU author(s): Dr Brendan PayneORCiD,
Professor Patrick Chinnery
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Mitochondrial DNA (mtDNA) mutations cause neurological and multisystem disease. Somatic (acquired) mtDNA mutations are also associated with degenerative diseases and with normal human ageing. It is well established that certain nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral drugs cause inhibition of the mtDNA polymerase, pol gamma, leading to a reduction in mtDNA content (depletion). Given this effect of NRTI therapy on mtDNA replication, it is plausible that NRTI treatment may also lead to increased mtDNA mutations. Here we review recent evidence for an effect of HIV infection or NRTI therapy on mtDNA mutations, as well as discussing the methodological challenges in addressing this question. Finally, we discuss the possible implications for HIV-infected persons, with particular reference to ageing.
Author(s): Payne BA, Gardner K, Chinnery PF
Publication type: Review
Publication status: Published
Journal: Antiviral Therapy
Print publication date: 01/01/2015
Online publication date: 17/07/2014
Acceptance date: 28/06/2014
ISSN (print): 1359-6535
ISSN (electronic): 2040-2058
Publisher: INT MEDICAL PRESS LTD