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Neuronal oscillations: a physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?

Lookup NU author(s): Felix Chan, Dr Nichola Lax, Emeritus Professor Doug Turnbull, Professor Mark Cunningham


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Increasingly in the realm of neurological disorders, particularly those involving neurodegeneration, mitochondrial dysfunction is emerging at the core of their pathogenic processes. Most of these diseases still lack effective treatment and are hampered by a shortfall in the development of novel medicines. Clearly new targets that translate well to the clinic are required. Physiological parameters in the form of neuronal network activity are increasingly being used as a therapeutic screening approach in drug development and disorders with mitochondrial dysfunction generally display neuronal network activity disturbance. However research directly linking the disturbances in neuronal network activity with mitochondrial dysfunction is only just starting to emerge. This review will summarize the breadth of knowledge linking neuronal network activity to mitochondrial dysfunction in neurodegenerative diseases and suggest potential avenues for exploration in respect to future drug development.

Publication metadata

Author(s): Chan F, Lax NZ, Davies CH, Turnbull DM, Cunningham MO

Publication type: Review

Publication status: Published

Journal: Neuropharmacology

Year: 2016

Volume: 102

Pages: 48-58

Print publication date: 01/03/2016

Online publication date: 28/10/2015

Acceptance date: 24/10/2015

ISSN (print): 0028-3908

ISSN (electronic): 1873-7064


DOI: 10.1016/j.neuropharm.2015.10.033