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An exploration of testosterone levels in patients with bipolar disorder

Lookup NU author(s): Dr Peter GallagherORCiD, Dr Stuart Watson



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Background Testosterone influences well-being, mood and cognition and may play a role in the pathophysiology of bipolar disorder.Aim To examine testosterone levels in patients with bipolar disorder compared with healthy controls.Method We examined baseline total testosterone levels and current depression scores in male and female patients with bipolar disorder and mild to moderate depression and healthy controls.Results A significant interaction between diagnosis and gender was observed (F(2,97)=9.791, P=0.002). Testosterone levels were significantly lower for male patients with bipolar disorder compared with male controls (P=0.001). Women with bipolar disorder had significantly higher testosterone levels than female controls (P=0.03).Conclusions Disturbances in testosterone levels may represent an important neurobiological abnormality in bipolar disorder and may differ by gender. If these findings are confirmed, the use of gender appropriate treatment strategies for the normalisation of testosterone levels in bipolar disorder depression should be further explored.

Publication metadata

Author(s): Wooderson SC, Gallagher P, Watson S, Young AH

Publication type: Article

Publication status: Published

Journal: British Journal of Psychiatry Open

Year: 2015

Volume: 1

Issue: 3

Pages: 136-138

Online publication date: 06/11/2015

Acceptance date: 16/10/2015

Date deposited: 11/11/2015

ISSN (electronic): 2056-4724

Publisher: Royal College of Psychiatrists


DOI: 10.1192/bjpo.bp.115.001008


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