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Process optimisation to control the physico-chemical characteristics of biomimetic nanoscale hydroxyapatites prepared using wet chemical precipitation

Lookup NU author(s): Dr Piergiorgio GentileORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Hydroxyapatite nanoscale particles (nHA) were prepared by wet chemical precipitation using four different synthesis methods. Differences in physico-chemical properties including morphology, particle-size, and crystallinity were investigated following alteration of critical processing parameters. The nanoparticles were also studied using X-ray diffraction (XRD), Fourier Transform infrared spectroscopy in attenuated total reflectance mode (FTIR-ATR), and transmission electron microscopy (TEM) with energy dispersive X-ray (EDS) spectrometry. The results showed that the particles obtained were composed of nHA, with different morphologies and aspect ratios (1.5 to 4) and degrees of crystallinity (40% to 70% following calcination) depending on the different process parameters of the synthesis method used, such as temperature, ripening time and pH. This study demonstrated that relatively small adjustments to processing conditions of different wet chemical preparation methods significantly affect the morphological and chemical characteristics of nHA. For the predicable preparation of biomimetic nHA for specific applications, the selection of both production method and careful control of processing conditions are paramount.

Publication metadata

Author(s): Gentile P, Wilcock CJ, Miller CA, Moorehead R, Hatton PV

Publication type: Article

Publication status: Published

Journal: Materials

Year: 2015

Volume: 8

Issue: 5

Pages: 2297-2310

Print publication date: 29/04/2015

Online publication date: 29/04/2015

Acceptance date: 20/04/2015

Date deposited: 07/01/2016

ISSN (electronic): 1996-1944

Publisher: MDPI


DOI: 10.3390/ma8052297


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