Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Poly(lactic acid)-based blends with tailored physicochemical properties for tissue engineering applications: a case study

Lookup NU author(s): Dr Piergiorgio GentileORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Binary blends of poly(L-lactic) acid (PLLA: 201790 Da) and poly(lactide-co-glycolide) (PLGA) (LA:GA = 50:50 mol:mol; 32030 Da) with various compositions were prepared. Physicochemical properties of PLLA/PLGA blends were analyzed. Blends showed a biphasic morphology, with distinct glass transition temperatures, which only slightly approximated compared to pure polymers. Analysis of tensile mechanical properties through the Kerner-Uemura-Takayanagi model showed compatibility for PLLA/PLGA 75/25 blend. Rapid degradation of PLGA phase (2–8 weeks) in PLLA/PLGA 75/25 blend led to porous samples, which appear promising for drug delivery and tissue engineering. A limited inflammatory reaction resulted from subcutaneous implantation of PLLA/PLGA 75/25 in Balb-c mice.

Publication metadata

Author(s): Carmagnola I, Nardo T, Gentile P, Tonda-Turo C, Mattu C, Cabodi S, Defilippi P, Chiono V

Publication type: Article

Publication status: Published

Journal: International Journal of Polymeric Materials and Polymeric Biomaterials

Year: 2014

Volume: 64

Issue: 2

Pages: 90-98

Print publication date: 16/10/2014

Online publication date: 16/10/2014

Acceptance date: 19/01/2014

ISSN (print): 0091-4037

ISSN (electronic): 1563-535X

Publisher: Taylor & Francis Inc.

URL: http://www.tandfonline.com/doi/abs/10.1080/00914037.2014.886247?journalCode=gpom20

DOI: 10.1080/00914037.2014.886247

Altmetrics

Altmetrics provided by Altmetric

Share