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Crosslinked gelatin nanofibres: preparation, characterization and in vitro studies using glial-like cells

Lookup NU author(s): Dr Piergiorgio GentileORCiD

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Abstract

Gelatin (GL) nanofibrous matrices mimicking the complex biological structure of the natural extracellular matrix (ECM) were prepared from aqueous solutions by electrospinning technique. GL nanofibres with a diameter size of around 300nm were obtained optimising the process and solution parameters. To increase the GL stability in aqueous environment γ-glycidoxypropyltrimethoxysilane (GPTMS) was used as GL crosslinker. GPTMS crosslinking did not modify the nanofibrous matrix morphology: fibre diameter and membrane pores size were 327±45 nm and 1.64±0.37 μm, respectively. The produced GPTMS crosslinked GL nanofibres (GL/GPTMS_NF) were found to support the in vitro adhesion, proliferation and survival of neonatal olfactory bulb ensheating cells (NOBECs).

Publication metadata

Author(s): Tonda-Turo C, Cipriani E, Gnavi S, Chiono V, Mattu C, Gentile P, Perroteau I, Zanetti M, Ciardelli G

Publication type: Article

Publication status: Published

Journal: Materials Science and Engineering C

Year: 2013

Volume: 33

Issue: 5

Pages: 2723–2735

Print publication date: 01/07/2013

Online publication date: 28/02/2013

Acceptance date: 20/02/2013

ISSN (electronic): 0928-4931

Publisher: Elsevier

URL: http://www.sciencedirect.com/science/article/pii/S0928493113001392

DOI: 10.1016/j.msec.2013.02.039

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