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STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?

Lookup NU author(s): Dr Henrique De Paula LemosORCiD, Dr Lei HuangORCiD, Emeritus Professor Andrew MellorORCiD


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DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer

Publication metadata

Author(s): Lemos H, Huang L, McGaha TL, Mellor AL

Publication type: Review

Publication status: Published

Journal: Expert Review of Clinical Immunology

Year: 2015

Volume: 11

Issue: 1

Pages: 155-165

Print publication date: 11/01/2015

Online publication date: 18/12/2014

Acceptance date: 01/01/1900

ISSN (print): 1521-6616

ISSN (electronic): 1521-7035


DOI: 10.1586/1744666X.2015.995097

PubMed id: 25521938