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Modulation of Host Biology by Pseudomonas aeruginosa Quorum Sensing Signal Molecules: Messengers or Traitors

Lookup NU author(s): Dr Chien-Yi ChangORCiD

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Abstract

Bacterial cells sense their population density and respond accordingly by producing various signal molecules to the surrounding environments thereby trigger a plethora of gene expression. This regulatory pathway is termed quorum sensing (QS). Plenty of bacterial virulence factors are controlled by QS or QS-mediated regulatory systems and QS signal molecules (QSSMs) play crucial roles in bacterial signaling transduction. Moreover, bacterial QSSMs were shown to interfere with host cell signaling and modulate host immune responses. QSSMs not only regulate the expression of bacterial virulence factors but themselves act in the modulation of host biology that can be potential therapeutic targets.

Publication metadata

Author(s): Liu YC, Chan KG, Chang CY

Publication type: Review

Publication status: Published

Journal: Frontiers in Microbiology

Year: 2015

Volume: 6

Online publication date: 09/11/2015

Acceptance date: 20/10/2015

ISSN (electronic): 1664-302X

Publisher: FRONTIERS MEDIA SA

URL: http://dx.doi.org/10.3389/fmicb.2015.01226

DOI: 10.3389/fmicb.2015.01226

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