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Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer’s disease

Lookup NU author(s): Dr Michael FirbankORCiD, Dr Rosemary Watson, Dr Benjamin Aribisala, Dr Robert Barber, Dr Sean Colloby, Dr Jiabao He, Professor Andrew BlamireORCiD, Professor John O'Brien



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Objective Changes in the white matter of dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) have been reported using diffusion weighted MRI, though few longitudinal studies have been done. Methods We performed diffusion weighted MRI twice, a year apart on 23 AD, 14 DLB, and 32 healthy control subjects. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated. Results In AD, there were widespread regions where the longitudinal MD increase was greater than in controls, and small areas in the parietal and temporal lobes where it was greater in AD than DLB. In AD, decrease in brain volume correlated with increased MD. There were no significant differences in progression between DLB and controls. Conclusions In AD the white matter continues to degenerate during the disease process, whereas in DLB, changes in the white matter structure are a relatively early feature. Different mechanisms are likely to underpin changes in diffusivity.

Publication metadata

Author(s): Firbank MJ, Watson R, Mak E, Aribisala B, Barber R, Colloby SJ, He J, Blamire AM, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Parkinsonism and Related Disorders

Year: 2016

Volume: 24

Pages: 76-80

Print publication date: 01/03/2016

Online publication date: 06/01/2016

Acceptance date: 05/01/2016

Date deposited: 06/01/2016

ISSN (print): 1353-8020

ISSN (electronic): 1873-5126

Publisher: Elsevier


DOI: 10.1016/j.parkreldis.2016.01.003


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Funder referenceFunder name
05/JTASir Jules Thorn Charitable Trust