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The neurocognitive profile of mood disorders – a review of the evidence and methodological issues

Lookup NU author(s): Dr Lucy Robinson, Dr Peter GallagherORCiD


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Objectives: Cognitive abnormalities are an established part of thesymptomatology of mood disorders. However, questions still existregarding the exact profile of these deficits in terms of the domains mostaffected, their origins, and their relationship to clinical subtypes. Thisreview aims to examine the current state of the evidence and to examineways in which the field may be advanced.Methods: Studies examining cognitive function in bipolar disorder (BD)and unipolar major depression (MDD) were examined. Given thenumber and variability of such studies, particular attention was paid tometa-analyses and to meta-regression analyses which examined thepossible mediators of cognitive impairment.Results: Meta-analyses are available for MDD and BD in bothdepression and euthymia. Several analyses examine mediators. Resultsdo not support the presence of domain specific deficits but rather amoderate deficit across a range of domains in BD and in MDD. Thedata on clinical mediators is inconsistent, even with regard to the effectof mood state.Conclusions: A two-tiered approach, with the broad-based applicationof standardized measures on a large-scale, and the refined application oftheoretically driven experimental development would significantlyfurther our understanding of neurocognitive processing in mooddisorder.

Publication metadata

Author(s): Porter RJ, Robinson LJ, Malhi GS, Gallagher P

Publication type: Article

Publication status: Published

Journal: Bipolar Disorders

Year: 2015

Volume: 17

Issue: Suppl. 2

Pages: 21-40

Online publication date: 21/12/2015

Acceptance date: 19/09/2015

ISSN (print): 1399-2406

ISSN (electronic): 1600-5511

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/bdi.12342


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