Browse by author
Lookup NU author(s): Dr Lucy RobinsonORCiD, Dr Peter GallagherORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Objectives: Cognitive abnormalities are an established part of thesymptomatology of mood disorders. However, questions still existregarding the exact profile of these deficits in terms of the domains mostaffected, their origins, and their relationship to clinical subtypes. Thisreview aims to examine the current state of the evidence and to examineways in which the field may be advanced.Methods: Studies examining cognitive function in bipolar disorder (BD)and unipolar major depression (MDD) were examined. Given thenumber and variability of such studies, particular attention was paid tometa-analyses and to meta-regression analyses which examined thepossible mediators of cognitive impairment.Results: Meta-analyses are available for MDD and BD in bothdepression and euthymia. Several analyses examine mediators. Resultsdo not support the presence of domain specific deficits but rather amoderate deficit across a range of domains in BD and in MDD. Thedata on clinical mediators is inconsistent, even with regard to the effectof mood state.Conclusions: A two-tiered approach, with the broad-based applicationof standardized measures on a large-scale, and the refined application oftheoretically driven experimental development would significantlyfurther our understanding of neurocognitive processing in mooddisorder.
Author(s): Porter RJ, Robinson LJ, Malhi GS, Gallagher P
Publication type: Article
Publication status: Published
Journal: Bipolar Disorders
Year: 2015
Volume: 17
Issue: Suppl. 2
Pages: 21-40
Online publication date: 21/12/2015
Acceptance date: 19/09/2015
ISSN (print): 1399-2406
ISSN (electronic): 1600-5511
Publisher: Wiley-Blackwell Publishing, Inc.
URL: http://dx.doi.org/10.1111/bdi.12342
DOI: 10.1111/bdi.12342
Altmetrics provided by Altmetric
