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Current Perspectives on Tissue Engineering for the Management of Limbal Stem Cell Deficiency

Lookup NU author(s): Dr Bakiah Shaharuddin, Dr Annette Meeson



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Limbal Stem Cell Deficiency (LSCD) encompasses a group of eye disorders characterized by abnormal maintenance of the limbal stem cells. This painful and potentially blinding condition poses a challenge in transplantation biology; whereby whole corneal transplantation would normally fail due to the depletion of the recipients’ limbal stem cells. The most preferred technique of management is transplantation of ex vivo expanded limbal stem cells to the damaged eyes. This article discusses the therapy options for unilateral and bilateral cases of LSCD, the clinical outcomes, components of cells and substrates that are currently being investigated or have been utilized by this technique, and brings into focus the newer therapy of using a scaffold-free cell delivery system to treat LSCD.

Publication metadata

Author(s): Shaharuddin B, Meeson A

Publication type: Review

Publication status: Published

Journal: Journal of Stem Cells Research, Reviews & Reports

Year: 2015

Volume: 2

Issue: 1

Pages: 1-8

Online publication date: 08/10/2015

Acceptance date: 01/10/2015

ISSN (electronic): 2381-9073