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Identification of translational dermatology research priorities in the UK: results of an electronic Delphi exercise

Lookup NU author(s): Professor Nick ReynoldsORCiD


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Background Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders.Objectives This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations.Methods During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups.Results Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease.Conclusions It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders.

Publication metadata

Author(s): Healy E, Brown SJ, Langan SM, Nicholls SG, Shams K, Reynolds NJ, UK TREND

Publication type: Article

Publication status: Published

Journal: British Journal of Dermatology

Year: 2015

Volume: 173

Issue: 5

Pages: 1191-1198

Print publication date: 01/11/2015

Online publication date: 14/10/2015

Acceptance date: 02/07/2015

ISSN (print): 0007-0963

ISSN (electronic): 1365-2133

Publisher: Wiley-Blackwell


DOI: 10.1111/bjd.14022


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Funder referenceFunder name
National Institute for Health Research
122403Canadian Institutes of Health Research (CIHR)
WT086398MAWellcome Trust