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Lookup NU author(s): Professor Catharien Hilkens
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Allergic reactions in atopic patients follow from a generalized enhanced polarization of Th cells, predominantly imposed by factors derived from antigen-presenting cells from a pathogen-stressed tissue; these sample information not only on antigen structures but also on the nature of the stress. Antigen-presenting cells of atopic individuals show aberrant characteristics which, through a highly interactive communication network, play an active role in aberrant Th-cell polarization. This generalized bias may follow from intrinsic abnormalities of antigen-presenting cells and also from a low degree of cross-regulation by micro-organisms.
Author(s): Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P
Publication type: Article
Publication status: Published
Journal: Current Opinion in Immunology
Print publication date: 01/12/1998
ISSN (print): 0952-7915
ISSN (electronic): 1879-0372
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