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Lookup NU author(s): Dr Wing Tong,
Professor Michael TaggartORCiD
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ProblemIs increased leukocyte chemotactic activity (CA) from gestational tissues necessary for term or preterm labor in guinea pigs?Method of StudyTissue extracts were prepared from pregnant guinea pig decidua-myometrium, cervix, fetal membranes (amniochorion), and placenta during early third trimester (n=8), term not in labor (TNL, n=5), and term spontaneous labor (TL, n=6), RU486-induced preterm labor (PTL, n=6), or controls (cPTL, n=5). Leukocyte CA was assessed using a modified Boyden chamber assay. Extract chemokine and maternal progesterone concentrations were quantified by enzyme immunoassay.ResultsOnly the extracts from amniochorion demonstrated increased CA through late gestation and labor. In contrast, CA was decreased in extracts from amniochorion and cervix from animals after RU486-induced PTL. Maternal progesterone concentrations remained high in all groups.ConclusionLeukocyte CA of intrauterine tissues is increased in term spontaneous labor. However, RU486-induced preterm labor occurs in the absence of increased CA.
Author(s): Gomez-Lopez N, Tong WC, Arenas-Hernandez M, Tanaka S, Hajar O, Olson DM, Taggart MJ, Mitchell BF
Publication type: Article
Publication status: Published
Journal: American Journal of Reproductive Immunology
Print publication date: 01/04/2015
Online publication date: 20/10/2014
Acceptance date: 23/09/2014
ISSN (print): 1046-7408
ISSN (electronic): 1600-0897
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