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Chemotactic Activity of Gestational Tissues Through Late Pregnancy, Term Labor, and RU486-Induced Preterm Labor in Guinea Pigs

Lookup NU author(s): Dr Wing Tong, Professor Michael TaggartORCiD

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Abstract

ProblemIs increased leukocyte chemotactic activity (CA) from gestational tissues necessary for term or preterm labor in guinea pigs?Method of StudyTissue extracts were prepared from pregnant guinea pig decidua-myometrium, cervix, fetal membranes (amniochorion), and placenta during early third trimester (n=8), term not in labor (TNL, n=5), and term spontaneous labor (TL, n=6), RU486-induced preterm labor (PTL, n=6), or controls (cPTL, n=5). Leukocyte CA was assessed using a modified Boyden chamber assay. Extract chemokine and maternal progesterone concentrations were quantified by enzyme immunoassay.ResultsOnly the extracts from amniochorion demonstrated increased CA through late gestation and labor. In contrast, CA was decreased in extracts from amniochorion and cervix from animals after RU486-induced PTL. Maternal progesterone concentrations remained high in all groups.ConclusionLeukocyte CA of intrauterine tissues is increased in term spontaneous labor. However, RU486-induced preterm labor occurs in the absence of increased CA.

Publication metadata

Author(s): Gomez-Lopez N, Tong WC, Arenas-Hernandez M, Tanaka S, Hajar O, Olson DM, Taggart MJ, Mitchell BF

Publication type: Article

Publication status: Published

Journal: American Journal of Reproductive Immunology

Year: 2015

Volume: 73

Issue: 4

Pages: 341-352

Print publication date: 01/04/2015

Online publication date: 20/10/2014

Acceptance date: 23/09/2014

ISSN (print): 1046-7408

ISSN (electronic): 1600-0897

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/aji.12333

DOI: 10.1111/aji.12333

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