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Restoring normoglycaemia by use of a very low calorie diet in long- and short-duration Type 2 diabetes

Lookup NU author(s): Dr Sarah Steven, Professor Roy Taylor


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AimsTo establish whether an 8-week very-low-calorie diet could improve glycaemic control in Type 2 diabetes of long duration.MethodsA total of 29 people with Type 2 diabetes [short-duration group (diabetes duration <4years), n=15; long-duration group (diabetes duration >8years), n=14] completed an 8-week very-low-calorie diet, with assessments of fasting anthropometry, blood tests and blood pressure at baseline and weeks 1, 4 and 8 of the diet.ResultsSimilar weight loss was achieved in the short- and long-duration groups (14.80.8% and 14.40.7% respectively; P=0.662). The glucose response to acute calorie restriction was heterogeneous in the long-duration group with some responding similarly to those in the short-duration group, some responding, but only slowly, and others not responding at all. Overall, HbA(1c) concentration in the short- vs. long-duration groups fell to 442 vs. 646mmol/l (6.20.2 vs. 8.0 +/- 0.5%; P=0.002). Fasting plasma glucose levels decreased to 5.8 +/- 0.2 vs. 8.4 +/- 1.1mmol/l (P=0.024) respectively. A total of 87% of the short-duration group and 50% of the long-duration group achieved non-diabetic fasting plasma glucose levels at week 8. Clinically significant improvements in blood pressure and lipid profile were seen regardless of diabetes duration.ConclusionIn people with Type 2 diabetes of >8years' duration, a therapeutic trial of a very-low-calorie dietmaybe undertaken with a 50% chance of achieving non-diabetic fasting glucose levels off all antidiabetic therapies.

Publication metadata

Author(s): Steven S, Taylor R

Publication type: Article

Publication status: Published

Journal: Diabetic Medicine

Year: 2015

Volume: 32

Issue: 9

Pages: 1149-1155

Print publication date: 01/09/2015

Online publication date: 26/02/2015

Acceptance date: 09/02/2015

ISSN (print): 0742-3071

ISSN (electronic): 1464-5491

Publisher: Wiley-Blackwell


DOI: 10.1111/dme.12722


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