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Neural correlates of unsuccessful memory performance in MCI

Lookup NU author(s): Dr Andreas FinkelmeyerORCiD, Felix Schneider



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


People with mild cognitive impairment (MCI) are at an elevated risk of developing Alzheimer's disease or other forms of dementia. Although the neural correlates of successful memory performance in MCI have been widely investigated, the neural mechanisms involved in unsuccessful memory performance remain unknown. The current study examines the differences between patients suffering from stable amnestic MCI with multiple deficit syndromes and healthy elderly controls in relation to the neural correlates of both successful and unsuccessful encoding and recognition. Forty-six subjects (27 controls, 19 MCI) from the HeIMA (Helmholtz Alliance for Mental Health in an Aging Society) completed a comprehensive neuropsychological test battery and participated in an fMRI experiment for associative face-name memory. In patients, the areas of frontal, parietal, and temporal cortices were less involved during unsuccessful encoding and recognition. A temporary dysfunction of the top-down control of frontal or parietal (or both) areas is likely to result in a non-selective propagation of task-related information to memory.

Publication metadata

Author(s): Chechko N, Drexler EI, Voss B, Kellermann T, Finkelmeyer A, Schneider F, Habel U

Publication type: Article

Publication status: Published

Journal: Frontiers in Aging Neuroscience

Year: 2014

Volume: 6

Online publication date: 13/08/2014

Acceptance date: 21/07/2014

Date deposited: 06/04/2016

ISSN (electronic): 1663-4365

Publisher: Frontiers Research Foundation


DOI: 10.3389/fnagi.2014.00201


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Funder referenceFunder name
Helmholtz Alliance "Mental Health in an Ageing Society" - Initiative and Networking Fund of the Helmholtz Association
N4-4IZKF Aachen