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Early haemodynamic changes observed in patients with epilepsy, in a visual experiment and in simulations

Lookup NU author(s): Dr Camillo Porcaro


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Objective: The objective of this study was to investigate whether previously reported early blood oxygen level dependent (BOLD) changes in epilepsy could occur as a result of the modelling techniques rather than physiological changes.Methods: EEG-fMRI data were analysed from seven patients with focal epilepsy, six control subjects undergoing a visual experiment, in addition to simulations. In six separate analyses the event timing was shifted by either -9, -6, +3,+ 3,+ 6 or +9 s relative to the onset of the interictal epileptiform discharge (IED) or stimulus.Results: The visual dataset and simulations demonstrated an overlap between modelled haemodynamic response function (HRF) at event onset and at +/- 3 s relative to onset, which diminished at +/- 6 s. Pre-spike analysis at -6 s improved concordance with the assumed IED generating lobe relative to the standard HRF in 43% of patients.Conclusion: The visual and simulated dataset findings indicate a form of "temporal bleeding'', an overlap between the modelled HRF at time 0 and at +/- 3 s which attenuated at +/- 6 s. Pre-spike analysis at -6 s may improve concordance.Significance: This form of analysis should be performed at 6 s prior to onset of IED to minimise temporal bleeding effect. The results support the presence of relevant BOLD responses occurring prior to IEDs. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Rollings DT, Assecondi S, Ostwald D, Porcaro C, McCorry D, Bagary M, Soryal I, Bagshaw AP

Publication type: Article

Publication status: Published

Journal: Clinical Neurophysiology

Year: 2016

Volume: 127

Issue: 1

Pages: 245-253

Print publication date: 01/01/2016

Online publication date: 17/07/2015

Acceptance date: 08/07/2015

ISSN (print): 1388-2457

ISSN (electronic): 1872-8952

Publisher: Elsevier


DOI: 10.1016/j.clinph.2015.07.008


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Funder referenceFunder name
EP/F023057/1UK Engineering and Physical Sciences Research Council (EPSRC)