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Lookup NU author(s): Dr Camillo Porcaro
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Objective: The objective of this study was to investigate whether previously reported early blood oxygen level dependent (BOLD) changes in epilepsy could occur as a result of the modelling techniques rather than physiological changes.Methods: EEG-fMRI data were analysed from seven patients with focal epilepsy, six control subjects undergoing a visual experiment, in addition to simulations. In six separate analyses the event timing was shifted by either -9, -6, +3,+ 3,+ 6 or +9 s relative to the onset of the interictal epileptiform discharge (IED) or stimulus.Results: The visual dataset and simulations demonstrated an overlap between modelled haemodynamic response function (HRF) at event onset and at +/- 3 s relative to onset, which diminished at +/- 6 s. Pre-spike analysis at -6 s improved concordance with the assumed IED generating lobe relative to the standard HRF in 43% of patients.Conclusion: The visual and simulated dataset findings indicate a form of "temporal bleeding'', an overlap between the modelled HRF at time 0 and at +/- 3 s which attenuated at +/- 6 s. Pre-spike analysis at -6 s may improve concordance.Significance: This form of analysis should be performed at 6 s prior to onset of IED to minimise temporal bleeding effect. The results support the presence of relevant BOLD responses occurring prior to IEDs. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Author(s): Rollings DT, Assecondi S, Ostwald D, Porcaro C, McCorry D, Bagary M, Soryal I, Bagshaw AP
Publication type: Article
Publication status: Published
Journal: Clinical Neurophysiology
Print publication date: 01/01/2016
Online publication date: 17/07/2015
Acceptance date: 08/07/2015
ISSN (print): 1388-2457
ISSN (electronic): 1872-8952
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