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Lookup NU author(s): Dr Mario Siervo
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Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5-day baseline diet in 19 adults with obesity confined to a metabolic ward where they exercised daily. Subjects received both isocaloric diets in random order during each of two inpatient stays. Body fat loss was calculated as the difference between daily fat intake and net fat oxidation measured while residing in a metabolic chamber. Whereas carbohydrate restriction led to sustained increases in fat oxidation and loss of 53 +/- 6 g/day of body fat, fat oxidation was unchanged by fat restriction, leading to 89 +/- 6 g/day of fat loss, and was significantly greater than carbohydrate restriction (p = 0.002). Mathematical model simulations agreed with these data, but predicted that the body acts to minimize body fat differences with prolonged isocaloric diets varying in carbohydrate and fat.
Author(s): Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L
Publication type: Article
Publication status: Published
Journal: Cell Metabolism
Year: 2015
Volume: 22
Issue: 3
Pages: 427-436
Print publication date: 01/09/2015
Online publication date: 13/08/2015
Acceptance date: 23/07/2015
ISSN (print): 1550-4131
ISSN (electronic): 1932-7420
Publisher: Cell Press
URL: http://dx.doi.org/10.1016/j.cmet.2015.07.021
DOI: 10.1016/j.cmet.2015.07.021
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