Toggle Main Menu Toggle Search

Open Access padlockePrints

Exploring strategies to operationalize cognitive reserve: A systematic review of reviews

Lookup NU author(s): Stephanie Harrison, Professor Bloss Stephan


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Introduction: The cognitive reserve hypothesis suggests that across the lifespan, higher education, regular participation in social or mentally stimulating activities, and complexity of occupation increase an individual's resistance to dementia. However, there is currently no consensus regarding how to assess or measure cognitive reserve. Method: We performed a systematic review of reviews focused on the concept of cognitive reserve to examine key elements of the definition and highlight limitations. We searched, MEDLINE (OvidSP), the Cochrane Library, Web of Science, Scopus, Google Scholar, and PubMed. Results: Five systematic reviews were identified. These incorporated findings from cohort, cross-sectional, and case-control studies, and the outcomes examined included Alzheimer's disease, vascular dementia, nonspecified dementia, all dementias, and cognitive decline or cognitive impairment. Education, occupation, and leisure or mentally stimulating activities were suggested to supply cognitive reserve and offer a protective effect against the risk of dementia. Premorbid IQ and socioeconomic status have not been investigated as thoroughly and showed inconsistent results. Two of the reviews showed that when combining different indicators in the analyses/definition, including education, occupation, mentally stimulating activities, and premorbid IQ, cognitive reserve had a protective effect against cognitive decline. However, other indicators may also supply the reserve, including dietary habits and genetic indicators, but research is lacking with regard to creating a full cognitive reserve model. Conclusions: This review highlights the lack of consensus regarding a definition of cognitive reserve. Further research is required to clarify how the indicators already identified may provide cognitive reserve and offer a protective effect against dementia. Agreement on the indicators that constitute the cognitive reserve model is needed before testing possible interventions that may increase the reserve supply and improve cognition.

Publication metadata

Author(s): Harrison SL, Sajjad A, Bramer WM, Ikram MA, Tiemeier H, Stephan BCM

Publication type: Review

Publication status: Published

Journal: Journal of Clinical and Experimental Neuropsychology

Year: 2015

Volume: 37

Issue: 3

Pages: 253-264

Online publication date: 09/03/2015

Acceptance date: 22/12/2014

ISSN (print): 1380-3395

ISSN (electronic): 1744-411X



DOI: 10.1080/13803395.2014.1002759