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Lookup NU author(s): Professor Bloss Stephan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
OBJECTIVETo determine whether the addition of data derived from magnetic resonance imaging (MRI) of the brain to a model incorporating conventional risk variables improves prediction of dementia over 10 years of follow-up.DESIGNPopulation based cohort study of individuals aged >= 65.SETTINGThe Dijon magnetic resonance imaging study cohort from the Three-City Study, France.PARTICIPANTS1721 people without dementia who underwent an MRI scan at baseline and with known dementia status over 10 years' follow-up.MAIN OUTCOME MEASUREIncident dementia (all cause and Alzheimer's disease).RESULTSDuring 10 years of follow-up, there were 119 confirmed cases of dementia, 84 of which were Alzheimer's disease. The conventional risk model incorporated age, sex, education, cognition, physical function, lifestyle (smoking, alcohol use), health (cardiovascular disease, diabetes, systolic blood pressure), and the apolipoprotein genotype (C statistic for discrimination performance was 0.77, 95% confidence interval 0.71 to 0.82). No significant differences were observed in the discrimination performance of the conventional risk model compared with models incorporating data from MRI including white matter lesion volume (C statistic 0.77, 95% confidence interval 0.72 to 0.82; P= 0.48 for difference of C statistics), brain volume (0.77, 0.72 to 0.82; P= 0.60), hippocampal volume (0.79, 0.74 to 0.84; P= 0.07), or all three variables combined (0.79, 0.75 to 0.84; P= 0.05). Inclusion of hippocampal volume or all three MRI variables combined in the conventional model did, however, lead to significant improvement in reclassification measured by using the integrated discrimination improvement index (P= 0.03 and P= 0.04) and showed increased net benefit in decision curve analysis. Similar results were observed when the outcome was restricted to Alzheimer's disease.CONCLUSIONSData from MRI do not significantly improve discrimination performance in prediction of all cause dementia beyond a model incorporating demographic, cognitive, health, lifestyle, physical function, and genetic data. There were, however, statistical improvements in reclassification, prognostic separation, and some evidence of clinical utility.
Author(s): Stephan BCM, Tzourio C, Auriacombe S, Amieva H, Dufouil C, Alperovitch A, Kurth T
Publication type: Article
Publication status: Published
Journal: BMJ
Year: 2015
Volume: 350
Online publication date: 22/06/2015
Acceptance date: 08/05/2015
Date deposited: 12/04/2016
ISSN (print): 1756-1833
Publisher: BMJ Publishing Group
URL: http://dx.doi.org/10.1136/bmj.h2863
DOI: 10.1136/bmj.h2863
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