Toggle Main Menu Toggle Search

Open Access padlockePrints

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

Lookup NU author(s): Professor Fiona MatthewsORCiD, Professor Bloss Stephan

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

BackgroundChanges in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).MethodsUniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.ResultsThe published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P <= .01).ConclusionApplying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.


Publication metadata

Author(s): Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, Brayne C, Matthews FE, Stephan BCM, Lipton RB, Katz MJ, Ritchie K, Carriere I, Ancelin ML, Lam LCW, Wong CHY, Fung AWT, Guaita A, Vaccaro R, Davin A, Ganguli M, Dodge H, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabarbara J, Cohort Studies Memory Internationa

Publication type: Article

Publication status: Published

Journal: PLoS One

Year: 2015

Volume: 10

Issue: 11

Online publication date: 05/11/2015

Acceptance date: 21/10/2015

Date deposited: 20/04/2016

ISSN (electronic): 1932-6203

Publisher: Public Library of Science

URL: http://dx.doi.org/10.1371/journal.pone.0142388

DOI: 10.1371/journal.pone.0142388


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
Fondazione Golgi Cenci and Federazione Alzheimer Italia
Novartis
Pfizer Foundation, Madrid
Department of Health
Eisai
UK Medical Research Council
01/0255Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
03/0815Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
03/121/17/214Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore
06/0617Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
08/1/21/19/567Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore
179805National Health and Medical Research Council of Australia
1002160National Health and Medical Research Council of Australia
350833National Health & Medical Research Council of Australia Program Grant
157125National Health and Medical Research Council of Australia
1R03 AG045474National Institute on Health/National Institute on Aging
5P01 AG003949National Institute on Health/National Institute on Aging
97/1321EFondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
973302National Health and Medical Research Council of Australia
568969National Health and Medical Research Council of Australia Program Grant
94/1562Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
98/0103Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
G03/128Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
P01 AG07232National Institute of Health/National Institute on Aging
R01 AG037212National Institute of Health/National Institute on Aging
R01AG07562National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services

Share