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The Developmental Origins of Osteoporosis

Lookup NU author(s): Dr Claire Wood, Professor Nicholas EmbletonORCiD


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Osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures. This article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non-modifiable risk factors in both intrauterine and postnatal life that contribute to the later onset of osteoporosis. Evidence for the effects of birth size and early growth in both preterm and term born infants are discussed and the role of epigenetics within the programming hypothesis is highlighted. This review provides compelling evidence for the developmental origins of osteoporosis and highlights the importance of osteoporosis prevention at all stages of the life course.

Publication metadata

Author(s): Wood CL, Stenson C, Embleton N

Publication type: Article

Publication status: Published

Journal: Current Genomics

Year: 2015

Volume: 16

Issue: 6

Pages: 411-418

Print publication date: 01/01/2015

Acceptance date: 01/01/1900

ISSN (print): 1389-2029

ISSN (electronic): 1875-5488

Publisher: Bentham Science Publishers Ltd.


DOI: 10.2174/1389202916666150817202217


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