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Lookup NU author(s): Dr Claire WoodORCiD, Professor Nicholas EmbletonORCiD
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Osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures. This article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non-modifiable risk factors in both intrauterine and postnatal life that contribute to the later onset of osteoporosis. Evidence for the effects of birth size and early growth in both preterm and term born infants are discussed and the role of epigenetics within the programming hypothesis is highlighted. This review provides compelling evidence for the developmental origins of osteoporosis and highlights the importance of osteoporosis prevention at all stages of the life course.
Author(s): Wood CL, Stenson C, Embleton N
Publication type: Article
Publication status: Published
Journal: Current Genomics
Year: 2015
Volume: 16
Issue: 6
Pages: 411-418
Print publication date: 01/01/2015
Acceptance date: 01/01/1900
ISSN (print): 1389-2029
ISSN (electronic): 1875-5488
Publisher: Bentham Science Publishers Ltd.
URL: http://dx.doi.org/10.2174/1389202916666150817202217
DOI: 10.2174/1389202916666150817202217
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