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Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe

Lookup NU author(s): Emeritus Professor Alan Craft


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Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70 % in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

Publication metadata

Author(s): Bolling T, Braun-Munzinger G, Burdach S, Calaminus G, Craft A, Delattre O, Deley MCL, Dirksen U, Dockhorn-Dworniczak B, Dunst J, Engel S, Faldum A, Frohlich B, Gadner H, Gobel U, Gosheger G, Hardes J, Hawkins DS, Hjorth L, Hoffmann C, Kovar H, Kruseova J, Ladenstein R, Leuschner I, Lewis IJ, Oberlin O, Paulussen M, Potratz J, Ranft A, Rossig C, Rube C, Sauer R, Schober O, Schuck A, Timmermann B, Tirode F, van den Berg H, van Valen F, Vieth V, Willich N, Winkelmann W, Whelan J, Womer RB

Publication type: Review

Publication status: Published

Journal: Klinische Paediatrie: clinical research and practice in pediatrics

Year: 2015

Volume: 227

Issue: 3

Pages: 108-115

Print publication date: 01/05/2015

Acceptance date: 01/01/1900

ISSN (print): 0300-8630

ISSN (electronic): 1439-3824



DOI: 10.1055/s-0035-1545263