Browse by author
Lookup NU author(s): Emeritus Professor Drew Rowan,
Dr Gary Litherland
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation-related pathologies such as diabetes, multiple sclerosis and cancer, very little is known about their roles in arthritis. The present review discusses current knowledge of the impact of TRIB on pro-inflammatory cellular mechanisms and pathways known to be important in the pathogenesis of RA and OA.
Author(s): Rowan AD, Litherland GJ
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 09/10/2015
Acceptance date: 01/01/1900
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press Ltd.
Altmetrics provided by Altmetric