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Lookup NU author(s): Dr Tom Jones
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses to carbohydrate (CHO) feeding during treadmill running. Ten men completed two 7-day trials, once being fed CHO (8% glucose immediately before, every 20 min during, and immediately after exercise at a rate of 0.7 g CHO.kg body mass(-1).h(-1)) and once being fed placebo (PBO). On day 4 of each trial, participants completed a 120-min treadmill run at 70% of maximal oxygen consumption ((V) over dotO(2 max)). Blood was taken at baseline (BASE), immediately after exercise (EE), after 60 (R1) and 120 (R2) min of recovery, and on three follow-up days (FU1-FU3). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (beta-CTX)] and formation [NH2-terminal propeptides of procollagen type 1 (P1NP)] were measured, along with osteocalcin (OC), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate, glucagon-like peptide-2 (GLP-2), interleukin-6 (IL-6), insulin, cortisol, leptin, and osteoprotogerin (OPG). Area under the curve was calculated in terms of the immediate (BASE, EE, R1, and R2) and short-term (BASE, FU1, FU2, and FU3) responses to exercise. beta-CTX, P1NP, and IL-6 responses to exercise were significantly lower in the immediate postexercise period with CHO feeding compared with PBO (beta-CTX: P = 0.028; P1NP: P = 0.021; IL-6: P = 0.036), although there was no difference in the short-term response (beta-CTX: P = 0.856; P1NP: P = 0.721; IL-6: P = 0.327). No other variable was significantly affected by CHO feeding during exercise. We conclude that CHO feeding during exercise attenuated the beta-CTX and P1NP responses in the hours but not days following exercise, indicating an acute effect of CHO feeding on bone turnover.
Author(s): Sale C, Varley I, Jones TW, James RM, Tang JCY, Fraser WD, Greeves JP
Publication type: Article
Publication status: Published
Journal: Journal of Applied Physiology
Year: 2015
Volume: 119
Issue: 7
Pages: 824-830
Print publication date: 01/10/2015
Online publication date: 06/08/2015
Acceptance date: 30/07/2015
Date deposited: 31/03/2016
ISSN (print): 8750-7587
ISSN (electronic): 1522-1601
Publisher: American Physiological Society
URL: http://dx.doi.org/10.1152/japplphysiol.00241.2015
DOI: 10.1152/japplphysiol.00241.2015
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